The product can be used with the eye open or closed. Shake before use; hold the bottle firmly, place the thumb on the dispenser taking care not to cover the nebuliser with your finger; hold the nebuliser about 10 cm from the eye, positioned to the side. If you use the product with your eyes open, keep your eyes looking forward so that the bottle is at the lateral edge of the visual field, then apply pressure to the dispenser to produce an effective solution spray. It is advisable to spray twice for each application, several times a day if required. Dispose of the device according to the local laws. Usable for 3 months after first use.